Histone acetyltransferases such as p300 and cAMP‐response element binding protein (CREP) have been shown to induce the acetylation of specific lysine residues through physically interacting with GATA4.50, 55 Analogous to phosphorylation, GATA4 acetylation is similarly recognized as an imperative stimulus‐triggered mechanism that regulates cardiac hypertrophy by enhancing its DNA binding efficiency and transcriptional activity. The gene discussed is EP300; the disease is cardiac hypertrophy.