GATA4 and congenital heart disease: For example, the heterozygous G296S missense mutation of GATA4 results in diminished DNA binding affinity, diminished transcriptional activity, and abolition of a physical interaction between GATA4 and TBX5 that is associated with congenital heart disease.17, 18 Moreover, four heterozygous missense GATA4 mutations, P36S, H190R, S262A, and V399G, have been linked to congenital atrial‐septal defects in new‐borns and are responsible for substantial morbidity and mortality in affected individuals.19