Histone acetyltransferases such as p300 and cAMP‐response element binding protein (CREP) have been shown to induce the acetylation of specific lysine residues through physically interacting with GATA4.50, 55 Analogous to phosphorylation, GATA4 acetylation is similarly recognized as an imperative stimulus‐triggered mechanism that regulates cardiac hypertrophy by enhancing its DNA binding efficiency and transcriptional activity. This evidence concerns the gene GATA4 and cardiac hypertrophy.