MMP10 and pulmonary emphysema: The MMP10 gene, which we identified here as a proteolysis related hub gene, is a potential COPD biomarker.47 It promotes emphysema development by influencing the proteolytic and inflammatory activities of macrophages.48 Knocking out the MMP10 gene in mice strongly attenuates emphysema‐like lung injury induced by cigarette smoke.49 Future study should examine MMP10 as a therapeutic target in emphysema.