Bik is anchored on the endoplasmic reticulum membrane, where it promotes calcium release from the endoplasmic reticulum, triggering mitochondrial apoptosis.45 Peptides derived from the Bik BH3 domain induce death of hyperplastic cells in bronchiolitis models, ultimately reducing the number of cigarette smoke‐induced mucous cells. The gene discussed is BIK; the disease is bronchiolitis.