miRNAs can modulate host gene expression and thereby inhibit or enhance HBV replication.137, 138, 139 The miR‐99 family promotes HBV replication post‐transcriptionally through insulin‐like growth factor 1 receptor (IGF‐1R)/phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt)/mTOR/ULK1 signaling‐induced autophagy.140 miR‐192‐3p is a regulator of HBV infection and may play a potential role in hepatocellular carcinoma. The gene discussed is AKT1; the disease is hepatocellular carcinoma.