It is well known that activation of NF‐κB p65 and its targets involved in the pathogenesis of autoimmune diseases, including IBD.37, 38 IL‐6, a cytokines critical to the pathogenesis of IBD, was found to dramatically increase in IECs transduced with Lv‐MCT4 compared with controls. This evidence concerns the gene NFKB1 and autoimmune disease.