The above results showed that MCT4 contributed to NF‐κB‐mediated inflammatory reaction and decreased CREB‐induced ZO‐1 expression that led to destroy barrier function, a critical step in the transcriptional regulation mediated by NF‐κB or CREB is the interaction of each of these transcription factors with the co‐activator CBP.39, 40 In order to better understand the driving forces controlling IBD by MCT4, we investigated the potential role of MCT4 in the complex of NF‐κB‐CBP and CREB‐CBP complex in IECs. The gene discussed is NFKB1; the disease is inflammatory bowel disease.