Most importantly, a significant reduction of IL‐6 was observed in DSS + CHC mice compared with that of DSS mice (Figure 7E), which was not only attributed to inhibit NF‐κB nuclear location (Figure 7G left panel), but also enhance CREB nuclear location (Figure 7G right panel) by CHC, leading to increase in ZO‐1 expression (Figure 7F). The gene discussed is CREB1; the disease is cryohydrocytosis.