To explore whether MCT4 contributed to IL‐6 expression by promotion of NF‐κB activity, we found that the relative abundance of NF‐κB p65 in nucleus was decreased to 25% of control group by CHC treatment (Figure 5E‐F), and NF‐κB p65 in nucleus was evaluated in colonic epithelial of patient with IBD compared with healthy donors (Figure 5G). This evidence concerns the gene IL6 and inflammatory bowel disease.