In conclusion, compared with 2018 AACC/IFCC criteria, improved selection criteria through questionnaire survey, physical examination, and laboratory screening to further exclude hypertension, overweight and obesity, and dyslipidemia can avoid overestimation of the 99th percentile URL of hs‐cTnT. The gene discussed is TNNT2; the disease is obesity due to melanocortin 4 receptor deficiency.