These M2 macrophages, which are conditioned from tumour‐derived IL‐10 or lactic acid, can secrete pro‐angiogenic mediators to promote angiogenesis, including basic fibroblast growth factor, placental growth factor, PDGF‐BB, and MMP9, as well as VEGF 45, 46, 47. The gene discussed is VEGFA; the disease is neoplasm.