INS and type 1 diabetes mellitus: Interestingly, a non-inferiority randomized controlled trial (RCT) comparing reduced dose of insulin (0.05 UI/kg/h) with standard recommended dose (0.10 UI/kg/h) in children with DKA including almost exclusively patients with type 1 diabetes reported significantly less metabolic events in the group receiving the reduced dose of insulin, without altering the recovery time [15].