The mean expression of GDF-9 in bovine COC cultured in PF from infertile women with endometriosis+curcumin (2.67 ± 0.98) increased compared to those cultured without curcumin (0.50 ± 0.67) but reduced compared to the control (5.83 ± 1.58). The gene discussed is GDF9; the disease is endometriosis.