The aim was to evaluate the effects of curcumin on growth factors expression by evaluating Growth Differentiation Factor-9 (GDF-9), Kit Ligand (KitL), and Tumor Necrosis Factor α (TNFα) expressions in bovine cumulus-oocyte complexes (COC)s cultured with PF from infertile women with endometriosis. This evidence concerns the gene GDF9 and endometriosis.