Vav2, which was correlated with E velocity at week 3 (r = 0.469, p = 4.12e−06), is a signal transduction molecule that activates Rho/Rac GTPases, the knockout of which in mice causes tachycardia, hypertension, defects in the heart, arterial walls and kidneys via chronic stimulation of the renin/angiotensin II and sympathetic nervous systems (19). The gene discussed is REN; the disease is hypertensive disorder.