Finally, week 3 A/E ratio also mapped to a locus near SNP rs28160199, which is in an intronic region of a non-coding RNA AK148321. Nearby SNPs in r2 > 0.8 LD with the lead SNP spanned across a region syntenic to the human 9p21 locus, containing ANRIL, CDKN2A, and CDKN2B, that has been associated with coronary artery disease, diabetes, and multiple cancers (26, 27). Here, CDKN2B-AS1 is linked to diabetes mellitus.