Finally, week 3 A/E ratio also mapped to a locus near SNP rs28160199, which is in an intronic region of a non-coding RNA AK148321. Nearby SNPs in r2 > 0.8 LD with the lead SNP spanned across a region syntenic to the human 9p21 locus, containing ANRIL, CDKN2A, and CDKN2B, that has been associated with coronary artery disease, diabetes, and multiple cancers (26, 27). The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.