Adamts2, which was significantly correlated with lung weight (r = 0.459, p = 5.49e−06), has been previously reported by our group to be a driver of cardiac hypertrophy (8) and confirmed by another group using gain- and loss-of-function genetic mouse model of Adamts2 to negatively regulate cardiomyocyte hypertrophy via the PI3K/AKT-dependent signaling pathway (18). The gene discussed is AKT1; the disease is cardiac hypertrophy.