BCL2 and acute myeloid leukemia: In another study, investigation of 53 fundamental proteins in 11 cell signaling pathways showed that AML cells responded differently to treatment with Mechanistic Target of Rapamycin (MTOR) inhibitor temsirolimus, B-cell lymphoma 2/B-cell lymphoma-extra large (BCL2/BCL-XL) antagonist ABT737, and mouse double minute 2 homolog (MDM2) inhibitor Nutlin-3a based on whether or not they were grown in the presence or absence of stromal tissue (67).