SPA17 and breast cancer: However, the number of MDA-MB-231 cells that migrated through the polycarbonate membrane was significantly higher than that of MDA-MB-231-siRNA cells at 48 h (MDA-MB-231 vs. MDA-MB-231-siRNA, p < 0.001; control vs. MDA-MB-231-siRNA, p < 0.001; MDA-MB-231 vs. control, p = 0.840; Figure 4J).These results demonstrated that SPA17 increased the invasion ability of breast cancer cells.