In another study, functional inhibition of the subgroup of IL-6- and IL-8-secreting CD10+GPR-77+ CAFs with anti-IL-6 and anti-IL-8 antibodies, together with docetaxel chemotherapy, has led to a near complete remission of tumors in a patient-derived xenograft (PDX) model of breast cancer (72). The gene discussed is C5AR2; the disease is breast cancer.