Remarkably, only those PSCs located away from tumor cells, denoted as “inflammatory CAFs (iCAFs),” were proficient in secreting pro-stemness factors, including IL-6, CXCL-1, and CXCL-2, through activation of IL-1α-Janus kina (JAK)–STAT signaling (55). The gene discussed is IL6; the disease is neoplasm.