Meanwhile, the expression of AEBP2 and ZNRF1 in high-tobacco exposed HNSCC was lower than those in low-tobacco and medium-tobacco exposed HNSCC, and the expression of AEBP2 and ZNRF1 in medium-tobacco exposed HNSCC was lower than those in low-tobacco exposed HNSCC (Figure 7). This evidence concerns the gene ZNRF1 and head and neck squamous cell carcinoma.