Functional analysis suggests that miR-326 is a potential tumor suppressor that regulates ErbB/PI3K signaling by targeting a network of genes (EGFR, ErbB2, ErbB3, AKT1, AKT2, and AKT3) linked to these pathways and therefore, possibly controls breast cancer cell proliferation, EMT, migration, and invasion. Here, AKT1 is linked to breast cancer.