Functional analysis suggests that miR-326 is a potential tumor suppressor that regulates ErbB/PI3K signaling by targeting a network of genes (EGFR, ErbB2, ErbB3, AKT1, AKT2, and AKT3) linked to these pathways and therefore, possibly controls breast cancer cell proliferation, EMT, migration, and invasion. The gene discussed is AKT1; the disease is breast carcinoma.