In the first frontline phase III study comparing a novel systemic therapy with standard therapies in CTCL, the randomized, open-label brentuximAb vedotin phase III trial for Cutaneous T-cell lymphomA aNalyZing pAtient outcomes (ALCANZA) study compared Bv to physician's choice of methotrexate or bexarotene in previously untreated CD30 positive CTCL (13). Here, TNFRSF8 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.