Of these, 2825 were systemic antibacterial (25.1% broad spectrum penicillin, 17.6% macrolide, 17.5% cephalosporin, 14.7% fluoroquinolone, 25.1% others), 448 medicines were used to treat diabetes (31.3% sulphonylurea, 25.5% biguanide, 25.9% insulin, 17.3% others) and 2113 to treat hypertension (5.3% methyldopa, 13.2% diuretic, 19.2% beta blocking agent, 16.7% calcium antagonist, 45.6% renin-angiotensin system agent). The gene discussed is REN; the disease is hypertensive disorder.