The role of the M2‐like macrophages including CD163+ macrophages in the pathogenesis of DLBCL is still controversial.27, 28, 29, 30, 31, 32, 33, 34, 35, 36 In this study, we showed that the total number of macrophages, that is Iba‐1+ macrophages, in the lymphoma tissues of IL‐34+ DLBCL patients who showed shorter survival periods, was significantly higher than that of IL‐34− patients (Figure 4). This evidence concerns the gene IL34 and diffuse large B-cell lymphoma.