Our study is aiming to, on both cellular and molecular levels, analyze the role of Notch and downstream genes, such as NF-κB, VEGF, before and after curcumin mediated PDT on cervical cancer cell, Me180; based on which, to further observe the influences of PDT on animal model of cervical cancer; identify the possible targets in PDT on cervical cancer by blocking Notch receptor. This evidence concerns the gene NFKB1 and cervical carcinoma.