Β-arrestin1 mRNA level co-relates with ATR and H2AX and β-arrestin 1 interacts with ATR and H2AX. To explore the potential relation between β-arrestin1, H2AX and ATR, we used quantitative real-time polymerase chain reaction (qRT-PCR) technic to investigate the mRNA level in 40 pairs of lung carcinoma and para-carcinoma tissues from Bio-bank, Shandong Provincial Hospital. The gene discussed is H2AX; the disease is lung carcinoma.