However, in lung cancer and pancreatic cancer, SMYD3 is localized in the cytoplasm and activates the ERK pathway by methylating MAP3K2.7, 11-13 Although SMYD3 is tightly connected to carcinogenesis, there are few articles about the role of SMYD3 in ovarian cancer. This evidence concerns the gene MAP3K2 and familial pancreatic carcinoma.