CD40LG and neoplasm: 30, 31 Bernd Koppold et al. reported that the transduction of tumor cells with recombinant adeno-associated virus (rAAV) encoding CD40L results in the strong activation of dendritic cells; these data helped the overexpression of CD40L become a promising strategy for tumor immunotherapy.32 When we knocked down SMYD3, CD40L expression increased by more than 10-fold in the HEY cell line.