DNM1L and malignant colon neoplasm: Inoue-Yamauchi et al. 23 found that siRNA-mediated Drp1 knockdown could promote elongated mitochondria accumulation in human colon cancer cells (HCT116 and SW480 cells) in vitro, and down-regulated Drp1 resulted in an increased cytochrome C (cyt-c) release and a greater than 30% increase in apoptosis rate.