In addition, as with the increased expression of PRDX2 in colorectal cancers, B cell‐derived primary lymphoma cells, and cervical cancer, etc. 22, similarly, we firstly found that PRDX-2 was positively expressed CCA cases but not expressed in choledochal cyst tissues, that is, the expression profile of PRDX2 in CCA is increased as compared with its expression in choledochal cyst tissues. This evidence concerns the gene PRDX2 and cholangiocarcinoma.