BGN and cholangiocarcinoma: Moreover, BGN up-regulation has been demonstrated in many malignancies such as pancreatic adenocarcinoma 27, prostate cancer 28, and colon cancers 24, etc. In addition, Nishino et al. 29 previously reported that BGN has the capacity of differentiating intrahepatic CCA from hepatocarcinoma or metastatic adenocarcinoma.