Intriguingly, we observed that the EIF4EBP2 pathway acting downstream of mTORC1, which is also a known regulator of beta cell proliferation in the pancreas, was also upregulated after Cenpx knockdown in T2DM mice (Supplementary Figure S6B) (Blandino-Rosano et al., 2017). This evidence concerns the gene EIF4EBP2 and type 2 diabetes mellitus.