In line with our preclinical findings, Melero, and co-workers recently published an interesting study in mouse colon cancer models, indicating that TNF blockers (anti-TNF or Etanercept) not only improves the anti-tumor effect of ICI (i.e., anti-PD-1 and anti-CTLA-4 combination) but also reduce irAEs (37). This evidence concerns the gene TNF and malignant colon neoplasm.