Two recent studies found that tumor-derived Wnt ligands can stimulate an anti-inflammatory tumor-associated-macrophage phenotype via β-cat signaling, which contributes to tumor growth, migration, metastasis, and immunosuppression via elevated expression of Arg1, Sti1, IL10, and decreased expression of IL1b, respectively [(29, 32); Figure 3]. This evidence concerns the gene ARG1 and neoplasm.