Within this frame it is tempting to speculate that in spontaneous tumors characterized by an inflamed microenvironment, tumor infiltrating CD4+ as well as CD8+ T cells by actively secreting IFNγ may transiently induce CIITA expression and consequently MHC class II gene expression in naïve tumor cells resulting in further recognition and killing of the tumor. The gene discussed is IFNG; the disease is neoplasm.