Moreover, a study by McClure et al showed that in late sepsis, binding of pSTAT3 and C/EBPβ to the miR-21 and miR-181b promoters is restricted to the CD31+ subset of Gr1+CD11b+ MDSCs, a more immature stage of Gr1+CD11b+ cells (8). This evidence concerns the gene ITGAM and Sepsis.