We followed a gene-centered approach to screen malaria association studies encompassing different clinical phenotypes, geographic regions, and Plasmodium species aiming to identify gene variants that have repeatedly produced evidence for positive association, namely in TNF, NOS2, IFNAR1, HMOX1, TLRs, CD36, and CD40LG genes (Supplementary Table 1). This evidence concerns the gene HMOX1 and malaria.