FOXP3 and neoplasm: By contrast, the number of FoxP3+ Tregs negatively correlated with total Th1 cytokines and the ratio of total Th1 cytokines to total Th2 cytokines in tumor tissues (R2 = 0.0963, P = 0.0051, and R2 = 0.1649, P = 0.0002, respectively; Figure 3C).