In addition, the modulatory effect of LMP on pancreatic immune responses during T1D was further confirmed by its suppressive effect on NLRP3 inflammasome activation (NLRP3, ASC, caspase-1 p20, cleaved IL-1β, and IL-18 expression) in the pancreas (Figure 7C). Here, NLRP3 is linked to type 1 diabetes mellitus.