Four out of 15 CGHD (n = 2 isolated GHD; n = 2 MPHD) and 13 out of 44 TGHD (n = 8 isolated GHD, n = 5 MPHD) showed a GH response to ITT ≥6 μg/L (Figure 1) despite the presence of known risk factors for high likelihood GHD as defined by the consensus (1), i.e. severe GHD in childhood with or without two or three additional hormone deficits, possibly due to a genetic abnormality, structural hypothalamic-pituitary abnormalities, central nervous system tumors or after high-dose cranial irradiation. The gene discussed is GH1; the disease is central nervous system neoplasm.