Based on these findings ROC curves were adjusted for either BMI or BMI SDS, showing that obesity could be a confounder (=lower peak) in interpreting the GH response in obese patients with MPHD (AUC 0.78 vs. 0.84; 95% CI, 0.67–0.89, and AUC 0.79 vs. 0.84; 95% CI, 0.68–0.89, respectively) (data not shown). This evidence concerns the gene GH1 and obesity due to melanocortin 4 receptor deficiency.