It is found to abnormally accumulate (in a similar manner to tau and amyloid-beta) in neuronal and glial protein inclusions, where it is hyperphosphorylated, ubiquitinated, and cleaved, in various neurodegenerative diseases including CTE, frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) (14, 15, 41). The gene discussed is MAPT; the disease is frontotemporal dementia.