MAPT and amyotrophic lateral sclerosis: It is found to abnormally accumulate (in a similar manner to tau and amyloid-beta) in neuronal and glial protein inclusions, where it is hyperphosphorylated, ubiquitinated, and cleaved, in various neurodegenerative diseases including CTE, frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) (14, 15, 41).