EDN1 and Schnyder corneal dystrophy: Regarding the interaction between the Gardos channel and a putative associated unknown receptor on the RBC membrane, a link was found between the endothelin receptor and Gardos activity with elevated levels of cytokines such as endothelin-1, interleukin-8, and platelet activator factor (PAF) in plasma of SCD patients: this disease is characterized by the intrinsic property of hemoglobin S to sickle under deoxygenation.