BSG and anemia (phenotype): Moreover, the group of Coste showed that CD147 plays a critical role in the re-entry of mature RBC from the spleen into the general circulation and when CD147 presence on the membrane was masked by antibody in mice, the migration out of the spleen was blocked and the RBC selectively trapped, inducing anemia and de novo erythropoiesis (Coste et al., 2001).