Defects in the biosynthesis of GPI causes paroxysmal nocturnal hemoglobinuria (PNH), a hematological disease characterized by increased intravascular hemolysis and complement activation due to the absence of CD55 and CD59 (Alegretti et al., 2012; Brodsky, 2015). This evidence concerns the gene CD59 and paroxysmal nocturnal hemoglobinuria.