Increased GH secretion has also been reported in female athletes compared with non-athletes (Laughlin and Yen, 1996), and in patients with anorexia nervosa with systemic low IGF-1 levels, indicating a hepatic GH resistance (Roemmich and Sinning, 1997; Misra and Klibanski, 2014). This evidence concerns the gene IGF1 and anorexia nervosa.