The activation of NLRP3 (Heneka et al., 2013; Heneka et al., 2014; Hughes and O’Neill, 2018), nucleotide oligomerization domain (NOD)-like receptor protein 1 (NLRP1) (Bernales et al., 2018), and NLR family CARD domain containing 4 (NLRC4) (Duncan and Canna, 2018), and the absence of Melanoma 2 (AIM2) (Denes et al., 2015) inflammasomes are all associated with various neurological diseases. This evidence concerns the gene NLRC4 and nervous system disorder.