Oxymatrine (OM). Many studies have proved that OM shows an anti-fibrotic effect on liver, pulmonary, myocardial and skin scar tissue fibrosis through inhibition of the TGF-β1/Smad signaling cascade (Shi and Li, 2005; Chen et al., 2008; Wu et al., 2008; Shen et al., 2011; Fan et al., 2012; Liu et al., 2012). The gene discussed is TGFB1; the disease is ocular melanoma.