A key target of the effects of NPCs may be in suppressing oxidative stress and the induction of 5′AMP-activated Kinase (AMPK), or suppression of the WNT/beta-catenin, PI3K/Akt/mTOR and RAS/MEK/ERK signaling pathways, among others, which results in cell death or prevents aging, diabetes, cardiovascular, cancer and other diseases (McCubrey et al., 2017). The gene discussed is AKT1; the disease is cancer.