GSK3B and Alzheimer disease: This presence of p-tau tangles also correlates with increased GSK3β activity, an observation that suggests GSK3β may be responsible for tau phosphorylation in PD, as it is in AD (Duka et al., 2009; Nagao and Hayashi, 2009; Wills et al., 2010; Golpich et al., 2015; Lazzara and Kim, 2015).