These data are consistent with a model in which dysfunctional Wnt-signaling in the AD brain causes GSK3β-mediated β-catenin depletion, which leads to a pathological decrease in the ratio of α-secretase to β-secretase expression (Figure 1Bi) and, thus, to an increase in the amyloidogenic processing of APP to Aβ (Mudher et al., 2001; Chami et al., 2012; Wan et al., 2012; Ly et al., 2013; De Ferrari et al., 2014; Llorens-Martín et al., 2014; Wan et al., 2014; Golpich et al., 2015; Parr et al., 2015). Here, GSK3B is linked to Alzheimer disease.