LRP6 and Alzheimer disease: Liu et al. not only found (1) lower LRP6 and β-catenin levels in the post-mortem brains of AD patients relative to age-matched control brains (Figure 1C), but also (2) a negative correlation between LRP6 and Aβ levels in these brains and (3) a positive correlation between LRP6 levels and Mini-Mental State Examination (MMSE) scores, a test in which higher scores indicate better cognitive function (Liu et al., 2014).