The complementary findings of the two mouse studies, in combination with the fact that Wnt ligands have been observed to increase AKT activity and neuronal glycolytic rate (Cisternas et al., 2016), hints at the possibility that dysfunctions in the insulin-AKT and Wnt-signaling pathways may cooperate to contribute to glucose metabolism deficiency in AD. Here, AKT1 is linked to Alzheimer disease.