Simply put, Wnt-signaling inhibits GSK3β, permitting β-catenin to accumulate in the cytoplasm and translocate into the nucleus to mediate the transcription of genes, such as BACE1 and ADAM10 (elaborated upon below), involved in the pathogenesis of AD (Rosso and Inestrosa, 2013; Figure 1A). This evidence concerns the gene GSK3B and Alzheimer disease.