Thus, as reviewed by Moussaud et al. (2014), there are at least three ways by which α-synuclein can instigate and aggravate tauopathy: by blocking the interaction between tau and microtubules, thereby interfering with tau’s physiological function (Figure 2Bi), by recruiting kinases that promote tau hyperphosphorylation (Figure 2Bii), and by seeding or chaperoning the aggregation of tau into neurotoxic oligomers andfibrils (Figure 2Biii). This evidence concerns the gene MAPT and tauopathy.