Although the mechanisms by which Aβ reciprocally induces α-synuclein likewise remains a gap in the literature, it is worth noting that upregulation of Wnt-signaling via β-catenin overexpression or GSK3β inhibition protects PD models from developing α-synuclein pathology and motor deficits (Yuan et al., 2015; Stephano et al., 2018). Here, SNCA is linked to Parkinson disease.