Interestingly, Wnt-signaling has been identified as necessary for GLUT1 expression at the blood-brain barrier (Daneman et al., 2009), and Pan et al. (2018) showed that inhibition of GSK3β in AD mice has precisely the opposite effects to those just described in that GSK3β inhibition increased cerebral blood flow, prevented Aβ accumulation, and rescued memory impairment. This evidence concerns the gene SLC2A1 and Alzheimer disease.