FXN and Friedreich ataxia: As frataxin deficiency has been reported to enhance production of cellular free radicals in patients and in KIKO cells (Abeti et al., 2018) and Nrf2 deficiency has been described in post-natal FRDA tissues and in frataxin-silenced motor neurons (D’Oria et al., 2013; Piermarini et al., 2016; Petrillo et al., 2017), we evaluated if KIKO NSCs exhibit Nrf2 impairment during neurogenesis.