Significantly, GSK3β activity has been shown to be abnormally activated by the AD associated oligomeric Aβ-42 peptide (oAβ-42) and by PrP (Perez et al., 2003; Pigino et al., 2009; Decker et al., 2010; Tang et al., 2012; Simon et al., 2014). Here, PRNP is linked to Alzheimer disease.