Another study showed that the role of the Aβ/PrPC complex in AD pathophysiology; the complex has been demonstrated to induce intracellular Fyn activation, leading to the further phosphorylation of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor and to the destabilization of dendritic spines (Um et al., 2012; Brody and Strittmatter, 2018). This evidence concerns the gene PRNP and Alzheimer disease.