PrPC is a high affinity receptor for oligomeric Aβ, and the expression of PrPC is important for Aβ-induced neurotoxicity, as demonstrated by the loss of long-term potentiation (LTP) and memory impairment in AD mouse models (Gimbel et al., 2010; Kostylev et al., 2015). Here, PRNP is linked to Alzheimer disease.