GRIN1 and Anxiety: • Hyperlocomotor activity, stereotypy, and decreased anxiety-like behavior in NR1 KD mice• Hyperlocomotor activity and stereotypy in GRIN1 compound het mice• Hyperlocomotor activity in cortical and hippocampal GABAergic Interneurons NR1 KO mice• Blunted MK-801-induced hyperlocomotor activity in PV-specific NR1 KO mice• Hyperlocomotor activity in forebrain pyramidal cells-specific NR1 KO mice