However, mPFC and sensory cortex pyramidal cells-specific NR1 KO mice only exhibit PPI and short-term memory impairments, suggesting that deletion of NR1 subunit in pyramidal neurons of broader forebrain regions may be required to induce a full range of symptoms of schizophrenia (Kehrer et al., 2008). The gene discussed is GRIN1; the disease is schizophrenia.