Hypomorphic NR1 mice with single point mutation in D481 (GRIN1D481N) are viable and exhibit increased startle reactivity, deficits in spatial recognition, spatial reference learning and memory, reduced sociability, anxiety, and sensitivity to NMDA-induced seizures, with impaired hippocampal LTP (Kew et al., 2000; Labrie et al., 2008). This evidence concerns the gene GRIN1 and Anxiety.