Phospho-Tau (Ser396) (P-Tau Ser396) detects endogenous levels of Tau only when phosphorylated at serine 396. Phosphorylation at Ser396 has shown to destabilize microtubules and contribute to different neurological disorders (Bramblett et al., 1993; Evans et al., 2000). Here, MAPT is linked to nervous system disorder.