This, in turn, explains the presence of ApoE, AChE and BuChE in the Aβ deposits (Mesulam and Geula, 1994; Ramanan et al., 2014), in particular in the brain of AD patients carrying APOE ε4 allele (Lehmann et al., 1997, 2000). The gene discussed is APOE; the disease is Alzheimer disease.