In more progressive neuropathologies, such as AD, both increased and decreased P2X7 expression was reported, by use of immunohistochemistry and [123I]TZ6019 in vitro ARX (Parvathenani et al., 2003; McLarnon et al., 2006; Janssen et al., 2018; Jin et al., 2018). Here, P2RX7 is linked to Alzheimer disease.