To better understand the relationship between P2X7 and neuroinflammation in PD, we employed two well-characterized models: the acute 6-hydroxydopamine (6-OHDA) toxin-induced model and the more progressive recombinant adeno-associated viral vector (rAAV2/7) model overexpressing A53T α-synuclein, which translates both the PD symptoms and histopathology (Van der Perren et al., 2015b). This evidence concerns the gene P2RX7 and Parkinson disease.