Orexin is also involved in the regulation of other functions including mood, cognition, response to stress, anxiety, and pain (Johnson et al., 2012; Flores et al., 2014; Muschamp et al., 2014; Yeoh et al., 2014; James et al., 2017a; Mavanji et al., 2017; Razavi and Hosseinzadeh, 2017). The gene discussed is HCRT; the disease is Anxiety.