Investigating the effect of this drug delivery system in transgenic mice demonstrated the inhibitory effect of nano spheres on Aβ aggregation and toxicity as well as decreasing inflammation in AD pathogenesis.38 In another study, Meng et al39 designed and engineered a novel low density lipoprotein (LDL)-mimic nanostructured lipid carrier (NLC) modified with lactoferrin (Lf)-loaded curcumin and evaluated the potency of novel synthesized nano-curcumin for brain-targeted delivery and its regulatory effect on progression of AD. The gene discussed is LTF; the disease is Alzheimer disease.