Additionally, liposomal formulation of curcumin increased the latency period and decreased the duration of clonic seizures during status epilepticus model of epilepsy.74 In another study, Rostami et al75 showed that there is a correlation between neuronal cell death and Klotho/erythropoietin (EPO) expression in an experimental model of chronic epilepsy. This evidence concerns the gene EPO and status epilepticus.