Il-6 induces significant physiological modifications, including activation and maintenance of low-grade systemic inflammation, disruption of EC homeostatic functions (impaired protection against reactive oxygen species [ROS]), EC dysfunction (reduced nitric oxide production, impaired relaxation, increased adhesion molecules, etc.), activation of monocytes, platelet aggregation, intimal proliferation, myocardial hypertrophy, and metabolic disturbance (leading to insulin resistance). This evidence concerns the gene IL6 and cardiac hypertrophy.