IL6 and Insulin resistance: Il-6 induces significant physiological modifications, including activation and maintenance of low-grade systemic inflammation, disruption of EC homeostatic functions (impaired protection against reactive oxygen species [ROS]), EC dysfunction (reduced nitric oxide production, impaired relaxation, increased adhesion molecules, etc.), activation of monocytes, platelet aggregation, intimal proliferation, myocardial hypertrophy, and metabolic disturbance (leading to insulin resistance).