CD4 and colitis: Furthermore, the addition of mixing with AICAR and C.C. increased the frequency of IFN-γ- and IL-17A-producing colitis LP CD4+ T cells in comparison to the addition of AICAR alone and decreased the frequency of IFN-γ- and IL-17A-producing colitis LP CD4+ T cells in comparison to the addition of C.C. alone (Fig. 3B,C).