Another study showed that AMPK activity was not involved in the reduction of inflammatory cytokines, such as IFN-γ and TNF-α, using WT-spleen CD4+ and CD8+ T cells in AMPK conditional knockout mice15; however, a precise analysis of the T cells infiltration in the immune mechanism-related IBD colon has not been performed. The gene discussed is TNF; the disease is inflammatory bowel disease.