MYC and cancer: Aberrant up-regulation of any MYC family member (MYC, MYCN, or MYCL) promotes metabolic reprograming that leads to sustained proliferation of cancer cells (Brodeur et al. 1984; Nau et al. 1985; Hatton et al. 1996; Beroukhim et al. 2010; Liu et al. 2012; Hsieh et al. 2015).