The PSCA gene rs2294008 C > T was found to significantly increase the risk of gastric cancer (CT vs. CC, OR = 1.55, 95% CI = 1.20–1.99, P<0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09–1.74, P=0.008). The gene discussed is PSCA; the disease is gastric cancer.